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KMID : 1007520150240062177
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Food Science and Biotechnology
2015 Volume.24 No. 6 p.2177 ~ p.2183
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A Partially Purified Lipid Extracted from Ruditapes philippinarum Suppresses Cancer Cell Proliferation
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Kim Eun-Kyung
Kim Yon-Suk
Hwang Jin-Woo
Moon Sang-Ho
Jeon Byong-Tae
Park Pyo-Jam
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Abstract
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Anticancer effects of lipids from a clam cultivated in Korea were investigated. Hexane extracts of Ruditapes philippinarum (R. philippinarum) exhibited the highest apoptosis rate of 40.9% at 0.5 mg/mL in PC3 cells. Hexane extracts were further separated and purified using TLC. Final lipid compounds were isolated and identified. Monounsaturated fatty acid and polyunsaturated fatty acid levels were significantly (p<0.05) increased in the purified lipid (19.71 and 34.63%), compared with the crude extract (12.96 and 15.56%). Partially purified lipid compounds exhibited an anticancer effect in several cancer cell lines, resulting in apoptosis rates in breast, lung, and liver cancer cells of 37.36, 17.78, 26.56%, respectively, at 30 μg/mL. This is the first report of an anticancer effect of a lipid extracted from R. philippinarum cultivated in Korea.
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KEYWORD
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Ruditapes philippinarum, lipid, apoptosis, anticancer
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